CDC Alert-Synthetic Cannabinoid-may contain-Brodifacoum (RAT POISON)

CDC Alert Synthetic Cannabinoid-(AKA-herbal incense-smoking blends, K2 & Spice) may contain Brodifacoum (rat poison)

The Centers for Disease Control has updated its warning that synthetic cannabinoids are being sold with brodifacoum a chemical used in rat poison, causing dangerous bleeding and death

  • Brodifacoum is a chemical used in rat poison can cause uncontrolled bleeding and death
  • Synthetic cannabinoids, also known as “herbal incense,” “herbal smoking blends,” “K2,” “Spice” and “Synthetic Marijuana,” is sold as an alternative to marijuana
  • Since CDC warning-March 8, 324 people have presented to healthcare facilities with serious bleeding from possible exposure (CDC, 2018)
  • Laboratory investigation confirmed brodifacoum exposure in at least 150 patients
    There have been at least eight (8) fatalities (CDC, 2018)
  • Brodifacoum compounds depress the hepatic synthesis of vitamin K1-dependent clotting factors (II, VII, IX, X) by inhibiting the vitamin K1 2,3-reductase enzyme in the vitamin K1-epoxide cycle. /Anticoagulant rodenticides/ (Pubchem, 2018)
  • In adults after intentional brodifacoum ingestion, the man plasma half-life was 30 days (range, 16 to 62 days) (Pubchem, 2018)


Autopsy findings in patients who died of complications from brodifacoum toxicity include,

  • hemarthrosis
  • pulmonary hemorrhages
  • renal calyceal hemorrhages
  • adrenocortical hemorrhage
  • petechial hemorrhages
  • subarachnoid, subdural, intraventricular, and intraparenchymal hemorrhages
    diffuse hemorrhagic diathesis


  • Vitamin K1 continues to be the recommended therapy as per CDC-for clinical treatment information see,



CDC: Fake marijuana can contain chemical used in rat poison-Norwalk Reflector (2018) ://

Update—Outbreak of Life-threatening Coagulopathy Associated with Synthetic Cannabinoids Use-CDC (2018) ://

Brodifacoum-Pubchem Open Chemistry Database (2018) ://

Brodifacoum-Pubchem Open Chemistry Database (2018) html://